The man on a quad-bike had attempted to cross Chambdor Road, moving from one track to another and in the course of doing so moved into the path of a light motor vehicle, Netcare 911 spokesperson Jeff Wicks said.
The man was struck by the vehicle and the force of impact threw him from the quad-bike.
He was found lying nearly 10m from the initial point of impact, Wicks said.
The man had sustained multi-system traumatic injuries and died at the scene.
The driver of the vehicle sustained serious facial trauma.
He was treated at the scene.