Netcare 911 paramedics and other services responded to an accident on Comaro Street in Oakdene, Alberton this morning.
Upon their arrival on scene they found that a heavy goods vehicle had left the roadway and collided with five women on the side of the road.
Two women tragically lost their lives while the other three women were found in a serious condition.
The women were treated on scene before they were transported to a nearby hospital for further medical care.
Exact detail to the cause of the accident and preceding events will remain the subject of a police investigation.