Netcare 911 paramedics and other services responded to an accident on the N3 Eastern Bypass near Marlboro drive in Modderfontein, Edenvale this morning.
Upon their arrival on scene they found that a heavy goods vehicle and five motor vehicles were involved in a rear-end collision.
Four people were found to be in a serious condition while a man was entrapped in his vehicle and found to be in a critical condition. Services had to make use of the Jaws of Life to extricate the man from his vehicle.
All the injured people were treated on scene before they were transported to hospital for further medical care.
Exact detail to the cause of the accident and preceding events will remain the subject of a police investigation