Netcare 911 paramedics and other services responded to an accident at the intersection of Stateway and Bultfontein Road in Welkom.
Upon their arrival on scene they found that a motor vehicle and heavy goods vehicle were involved in a side-impact accident resulting in three people sustaining moderate injuries and one person sustaining serious injuries.
All the injured people were treated on scene before they were transported to hospital for further medical care.
Exact detail to the cause of the accident and preceding events will remain the subject of a police investigation.