Netcare 911 paramedics and other services responded to an accident on Main Road in Kwa-Dukuza this afternoon.
Upon their arrival on scene they found that two light delivery vehicles were involved in a side-impact collision.
Kwa-Dukuza Fire Department had to make use of the Jaws of Life to extricate an entrapped person.
Two people sustained serious injuries and were transported to hospital after receiving treatment on scene.
Exact detail to the cause of the accident and preceding events will remain the subject of a police investigation.