Netcare 911 paramedics and other services responded to an accident on the R102 Etete road north of Shakaskraal.
Upon their arrival on scene they found that a motor vehicle and minibus had collided resulting in two people found to be in a serious condition and two people sustaining moderate injuries.
All the injured patients were treated on scene before they were transported to hospital for further medical care.
Exact detail to the cause of the accident and preceding events will remain the subject of a police investigation.