Netcare 911 paramedics and other services responded to a collision on the N3 South bound near Van Reenen last night.
Upon their arrival on scene they found that two heavy goods vehicles collided head-on resulting in four men sustaining moderate injuries. One of the heavy goods vehicles burst into flames.
All the injured people were treated on scene before they were transported to a nearby hospital for further medical care.
Exact details to the cause of the accident and preceding events will remain the subject of a police investigation.